• Homesquare
  • Recent Winssquare
  • Stable Epinephrine Suspensionn Formulation with high Inhalation Delivery Efficiency

Gao et al.

Patent Stable Epinephrine Suspensionn Formulation with high Inhalation Delivery Efficiency

Reg. #8367734
Awarded Feb. 5, 2013

Attorneys: Thomas J. Daly, Justin O. Ehresmann

A stable suspension aerosol formulation of epinephrine is suitable for administration through inhalation comprising a therapeutically effective amount of epinephrine, hydrofluorocarbon propellant, co-solvent, surfactant, and antioxidant. The suspension aerosol formulation further comprises pre-micronized epinephrine suspended in an alcohol/surfactant solution with hydrofluoroalkane propellant. The suspension formulation provides a highly efficient delivery of drug microparticles into the respirable region of patients' lungs and has the following advantages: lower dosage requirement, minimum alcohol content, with less impurities generated during storage, improved efficacy and safety, and exhibits no ozone depleting potential compared to a formulation containing chlorofluorocarbon.

Download Patent Application